Stress ulcer prophylaxis: Is mortality a useful endpoint?

Survey of stress ulcer prophylaxis

BACKGROUND: No surveys of stress ulcer prophylaxis prescribing in the USA have been conducted since 1995. Since that time, the most comprehensive meta-analysis and largest randomized study to date concerning stress ulcer prophylaxis have been published. RESULTS: Three hundred sixty-eight surveys were sent to all members of the Section of Pharmacy and Pharmacology of the Society of Critical Care...

Stress Ulcer Prophylaxis Deadoption: What is the Barrier?

Stress ulcer prophylaxis in trauma patients

INTRODUCTION A number of issues concerning stress ulcer prophylaxis remain unresolved despite numerous randomized, controlled trials and several meta-analyses. The role of stress ulcer prophylaxis, particularly in trauma patients, is further complicated by the lack of trials utilizing clinically important bleeding as an endpoint. Given the lack of consensus regarding stress ulcer prophylaxis in...

A cost-effectiveness analysis of stress ulcer prophylaxis.

OBJECTIVE To evaluate the efficacy, safety, and cost of using cimetidine, famotidine, and lansoprazole for stress ulcer prophylaxis (SUP) at our institution and determine which agent was most cost-effective. METHODS An observational study of adults admitted to the medical, surgical, or cardiovascular intensive care unit was conducted to compare the cost and effectiveness of cimetidine, famoti...

Is estimating maternal mortality useful?

In this issue, Hill, AbouZahr &Wardlaw (1) present new estimates of maternal mortality for 1995. They have carefully adjusted the data for underreporting, and used statistical models in countries lacking relevant data. They have obtained a global estimate ranging from some 303 000 to 822 000 maternal deaths. This very large range is mostly the consequence of the limited quality of available dat...